Ultrastructural lesions of pyridoxine toxicity in beagle dogs.

A 90-day Repeat-Dose Oral Toxicity Study of Yonkenafil Hydrochloride in Beagle Dogs

Yonkenafil hydrochloride, a novel synthetic phosphodiesterase type 5 inhibitor, is a promising drug for the treatment of erectile dysfunction. The repeated-dose toxicity of yonkenafil hydrochloride was assessed in male and female beagle dogs. Twenty-four dogs were randomly allocated to four groups and administered yonkenafil hydrochloride orally at dosages of 0, 7, 30 or 120 mg/kg/day for 90 da...

Localization of Helicobacter spp. in the fundic mucosa of laboratory Beagle dogs: an ultrastructural study

In dogs Helicobacter spp. are found in all gastric regions usually localized in the surface mucus, gastric glands and parietal cells. The aim of this study was to detail the distribution of Helicobacter spp. in the fundic mucosa of asymptomatic Beagle dogs and their intracellular localization within parietal cells, in order to evaluate species-specific pathogenetic effects on gastric cells. The...

Seasonal and circadian variations of hemodynamic and electrocardiographic parameters in telemetered beagle dogs

organophosphate pesticide in Beagle dogs

Organophosphate compounds, which are potent irreversible inhibitors of carboxylic esterases, including cholinesterase, have been extensively used as pesticides throughout the world, and many unfortunate incidents of acute intoxication have been reported (Grob and Harvey, I953; Goldman and Teitel, I958; Healy, 1959; Dinman, I964; Quinby, I964; Crowley and Johns, I966; DePalma, Kwalick, and Zuker...

Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs.

AIM OF THE STUDY To investigate subchronic toxicity and pharmacokinetic of wogonin using Beagle dog and to provide foundation for clinical applications of this promising anticancer agent. MATERIALS AND METHODS Wogonin was administered via intravenous infusion at dosages of 60, 30 and 15 mg/kg per day for 90 days followed by subchronic toxicity studies including general body parameters, hemato...